Working Group 3
WG3. Pathogenesis and Tumour Profiling
Unravelling brain cancer pathogenesis through single-cell and multi-omics profiling for patient stratification and treatment optimisation.
WG3
Objectives
Pathogenesis & Tumour Profiling (Theme 3) uses single-cell resolution and multi-omics to unravel tumour pathogenesis, revealing the regional heterogeneity of cancer and supporting patient stratification.
- Objectives. To unravel the mechanisms of brain cancer pathogenesis and optimise preclinical models, aligning with RCO2 and RCO3.
- Tasks. T3.1 Improve best practices in single-cell techniques for patient stratification; T3.2 Conduct spatial analyses of intratumoral heterogeneity regarding subclonal evolution and treatment response; T3.3 Organise WG3 collaborative meetings.
- Activities. Active participation in MC and WG3 meetings; co-organising a joint WG2/WG3 conference; contributing to annual and final reports, two peer-reviewed joint publications, and dissemination, exploitation and training activities.
- Milestones. M3.1 WG2/WG3 joint conference — Month 22; M3.2 Mid-term report — Month 25.
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