Working Group 2
WG2. Preclinical Modelling
Development of more accurate GEMMs and PDOX models, plus 3D systems — neurospheres, organoids and bioprinting — to understand brain tumour mechanisms.
WG2
Objectives
Preclinical Modelling (Theme 2) develops more accurate GEMMs and patient-derived orthotopic xenografts (PDOXs), plus 3D systems — neurospheres, organoids and bioprinting — to understand brain tumour mechanisms and responses to innovative therapies.
- Objectives. To design advanced pre-clinical models that reveal the pathogenesis of brain cancer. Relevant to RCO2 and RCO3.
- Tasks. T2.1 Improve preclinical modelling (new animal models, organoids, 3D models, bio-printed scaffolds); T2.2 Improve single-cell techniques for patient stratification; T2.3 WG2 meetings.
- Activities. Involvement in all MC and WG2 meetings, co-organisation of a WG2/WG3-focused conference, contributions to annual and final reports, publications, dissemination, exploitation and training schools.
- Milestones. M2.1 WG2/WG3 conference — Month 22; M2.2 Mid-term report — Month 25.
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